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Large-scale cohort data published in JAMA Internal Medicine demonstrates that updated COVID-19 vaccination is associated with a significant reduction in major adverse cardiovascular events. Studying over one million United States veterans, researchers identified an approximate thirty percent decrease in the composite risk of acute myocardial infarction, ischemic stroke, and all-cause cardiovascular mortality among vaccinated individuals. SARS-CoV-2 infection induces profound systemic endothelial
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