Alternative splicing represents a critical layer of gene regulation that greatly diversifies the expression of transcript and protein isoforms from a limited repertoire of genes. Transcripts from over ...

Single-cell spatial transcriptomes have demonstrated molecular and cellular diversity in the brain, but gene regulatory mechanisms underlying transcriptomic profiles and disease pathogenesis remain ...

Scientists from Duke-NUS Medical School and their collaborators have created one of the most comprehensive single cell maps of the developing human brain. The atlas captures nearly every cell type, ...

Developing neocortex in Down syndrome. IT neurons are labeled in magenta and deep-layer neurons in green. IT and double-positive neurons are increased in DS at this stage [de la Torre-Ubieta Lab] A ...

Immunology researchers are working to understand complex adaptive immune responses, but meaningful signals are often rare, transient, or difficult to capture across large, sample-limited studies.