Using human liver samples and a mouse model of cirrhosis, researchers identified epigenetic overactivation of the inflammatory PAF–PAF-R pathway in hepatic macrophages as a key driver of liver damage.

Fats are an important part of the human diet as a major source of energy. Around 90% of the fat stores are on top of muscle, so just under the skin. However, excessive dietary fat intake leads to fat ...

Never-before-seen 3D reconstructions of human liver tissue have been created at a cellular level. The details obtained by a team of UW Medicine and University of Washington engineers and physicians ...

Over time, this damages liver cells, triggers inflammation and contributes to fibrosis, which is the build-up of scar tissue. If scarring becomes extensive, it can progress to cirrhosis, a stage where ...

More than 10,000 Americans who suffer from chronic liver disease are on a waitlist for a liver transplant, but there are not ...

Scientists have developed injectable "mini livers" that can replicate liver function, potentially buying time for those with ...