Biological aging is associated with progressively more severe genetic and epigenetic alterations. While these changes are expected to affect the transcriptional profile of cells, the magnitude of that ...

Despite the manifestation and contribution of cellular senescence to aging and various diseases, accurate identification of heterogeneous senescent cells remains challenging. Current senescence ...

At the turn of the century, the biomedical research community saw a landmark global effort, when scientists built a reference human genome sequence to better understand the genes underlying health and ...

A multi-institutional team led by the Chinese Academy of Sciences has constructed a proteomic atlas of human aging across 13 organs, revealing tissue-specific aging clocks, transcriptome-proteome ...