The human brain comprises billions of neurons, synapses, and cell types, making it one of the universe’s most intricate and dynamic structures. However, the complexity and sensitivity of the brain can ...

Peptide conjugation techniques are advancing CNS delivery of oligonucleotides, addressing blood-brain barrier challenges and improving therapeutic outcomes.

Nanoparticle-based drug delivery systems utilise the unique physicochemical properties of nanoscale carriers to enhance therapeutic efficacy whilst minimising systemic side effects. These formulations ...

While this protects the brain from external threats, it also presents a major challenge for treating neurological diseases, as many potentially therapeutic compounds are unable to cross. One potential ...

Drug-loaded albumin NPs hijack calvarial immune cells to bypass the BBB via skull-meninges microchannels for CNS drug delivery and stroke therapy, establishing skull-based delivery and immune-assisted ...

Research teams have created a versatile set of gene delivery systems that can reach different neural cell types in the human brain and spinal cord with exceptional accuracy. These delivery systems are ...

When patients undergo general anesthesia, doctors can choose among several drugs. Although each of these drugs acts on neurons in different ways, they all lead to the same result: a disruption of the ...

The blood–brain barrier functions as an evolutionarily optimized vascular “filter,” permitting limited penetration of small molecules like temozolomide while effectively excluding most biologics from ...

New studies stemming from the Armamentarium consortium outline findings that advance tools based on Adeno-associated virus (AAV) vectors. An announcement about the work explains how an AAV "acts like ...

The human brain comprises billions of neurons, synapses, and cell types, making it one of the universe's most intricate and dynamic structures. However, the complexity and sensitivity of the brain can ...