Highly-sensitive transcriptomic analysis clarifies the maturation pathway of basophils, one of the rarest immune cells that contribute to allergic inflammation. Credit: Inflammation, Infection & ...

Basophils are white blood cells that the bone marrow makes. They play a role in a healthy immune system. Levels that are higher or lower than usual may be a sign of inflammation, hyperthyroidism, or ...

Indolent systemic mastocytosis (ISM) is a type of mastocytosis in which fewer clonal mast cells accumulate, thereby slowing the disease course and offering a better prognosis than other, more ...

Researchers from Tokyo Medical and Dental University (TMDU) find that pre-basophil and mast cell progenitors differentiate into pre-basophils before producing mature basophils in mice Tokyo, Japan – ...

Inflammation is a crucial part of the body's defense mechanism, playing a key role in fighting infections and repairing tissue damage. Basophils, a type of immune cell that makes up less than 1% of ...

In experiments with ARDS model mice, researchers from Japan found that basophils, a type of white blood cells, release interleukin-4, a signaling molecule that suppresses inflammatory neutrophils ...

C. Ohnmacht et al., “Basophils orchestrate chronic allergic dermatitis and protective immunity against helminths,” Immunity, 33:364-74, 2010. Free F1000 Evaluation Basophils were deemed critical in ...

The researchers identified 411 patients with PMF who had baseline basophil and eosinophil counts available at the time of diagnosis or first referral. After a median follow-up of 52 months, most ...